Caenorhabditis elegans germ line: A model for stem cell biology
نویسندگان
چکیده
منابع مشابه
Translational control in the Caenorhabditis elegans germ line.
Translational control is a prevalent form of gene expression regulation in the Caenorhabditis elegans germ line. Linking the amount of protein synthesis to mRNA quantity and translational accessibility in the cell cytoplasm provides unique advantages over DNA-based controls for developing germ cells. This mode of gene expression is especially exploited in germ cell fate decisions and during oog...
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Sexual identity is one of the most important factors that determine how an animal will develop. Although it controls many dimorphic tissues in the body, its most ancient role is in the germ line, where it species that some cells become sperm, and others become eggs. In most animals, these two fates occur in distinct sexes. However, certain nematodes like C. elegans produce XX hermaphrodites, wh...
متن کاملGerm-line induction of the Caenorhabditis elegans vulva.
Development of the Caenorhabditis elegans vulva serves as a paradigm for intercellular signaling during animal development. In wild-type animals, the somatic gonadal anchor cell generates the LIN-3/EGF ligand to induce vulval fates in the underlying hypodermis, whereas FBF, FOG-1, and FOG-3 control germ-line development. Here we report that FBF functions redundantly with FOG-1 and FOG-3 to cont...
متن کاملPurpose and regulation of stem cells: a systems-biology view from the C. elegans germ line
Abstract Stem cells are expected to play a key role in the development and maintenance of organisms, and hold great therapeutical promises. However, a number of questions must be answered to achieve an understanding of stem cells and put them to use. Here I review some of these questions, and how they relate to the model system provided by the C. elegans germ line, which is exceptional by its t...
متن کاملRadiation biology of Caenorhabditis elegans: germ cell response, aging and behavior.
The study of radiation effect in Caenorhabditis (C.) elegans has been carried out over three decades and now allow for understanding at the molecular, cellular and individual levels. This review describes the current knowledge of the biological effects of ionizing irradiation with a scope of the germ line, aging and behavior. In germ cells, ionizing radiation induces apoptosis, cell cycle arres...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2007
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.21335